INTRODUCTION: To evaluate the performance of first trimester nuchal translucency scan screening among pregnant women in Nigeria.Methods: A prospective observational and questionnaire based study involving 510 pregnant women between 11+0 and 13+6 weeks.Routine counselling and nuchal translucency measurement was conducted using the FMF, London guidelines.Chorionic villous sampling was done at NT = 2.
5 mm or = 95th centile.METHODS: A prospective observational and questionnaire based study involving 510 pregnant women between 11+0 and 13+6 weeks.Routine counselling and nuchal translucency measurement was conducted using the FMF, London guidelines.
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.Chorionic villous sampling was done at NT greater than 2.
5 mm or greater than 95th centile.RESULTS: Five hundred and ten out of 542 (94.1%) were analysed, mainly referred by health care workers (87.2%) and from predominantly private facilities (94.
3%).The number of NT scans performed increased in successive years with corresponding decrease in the mean scanning time.Scan was successfully completed at first attempt in (96.5%), with mean scanning time of 28.
3 minutes.Nuchal translucency increases with gestational but not maternal age.The median and 95th centile at 11+0 week was 1.2mm and 1.
7 mm and at 13+6 weeks was 1.5 mm and 2.2 mm.Using a cut-off of 2.
5 mm or 95th centile, 17 (3.3%) screened positive.Three out of the 17 had invasive testing and 2 (DR = 66.7%) were confirmed trisomy 21, with a false positive rate of 5.
9%.Although majority (86.4%) were willing to have invasive testing, only few (3 or 17.
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.6%) of the high risk group had testing.
CONCLUSION: The study demonstrated that NT scan is feasible as a screening tool in pregnancy in Nigeria.Measures of improving utilization include wider dissemination of information, provision of dedicated NT clinics and manpower training